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Si existen dependencias:

sudo dpkg -i virtualbox-4.2_4.2.2-81494~Debian~wheezy_amd64.deb 

Selecting previously unselected package virtualbox-4.2.
(Reading database ... 68581 files and directories currently installed.)
Unpacking virtualbox-4.2 (from virtualbox-4.2_4.2.2-81494~Debian~wheezy_amd64.deb) ...
dpkg: dependency problems prevent configuration of virtualbox-4.2:
 virtualbox-4.2 depends on libqt4-network (>= 4:4.5.3); however:
  Package libqt4-network:amd64 is not installed.
 virtualbox-4.2 depends on libqt4-opengl (>= 4:4.7.2); however:
  Package libqt4-opengl:amd64 is not installed.
 virtualbox-4.2 depends on libqtcore4 (>= 4:4.8.0); however:
  Package libqtcore4:amd64 is not installed.
 virtualbox-4.2 depends on libqtgui4 (>= 4:4.8.0); however:
  Package libqtgui4:amd64 is not installed.

dpkg: error processing virtualbox-4.2 (--install):
 dependency problems - leaving unconfigured
Processing triggers for shared-mime-info ...
Processing triggers for hicolor-icon-theme ...
Errors were encountered while processing:
 virtualbox-4.2

SOLUCION

sudo apt-get install -f
sudo dpkg -i virtualbox-4.2_4.2.2-81494~Debian~wheezy_amd64.deb